Accuracy of a Flash Glucose Monitoring System in Diabetic Dogs

J Vet Intern Med. 2016 Jul;30(4):983-8. doi: 10.1111/jvim.14355. Epub 2016 Jun 18.

Abstract

Background: A novel flash glucose monitoring system (FGMS) (FreeStyle Libre, Abbott, UK) was recently developed for humans. It continuously measures the interstitial glucose (IG) concentrations for 14 days.

Objectives: To assess the clinical and analytical accuracy of the FGMS in diabetic dogs.

Animals: Ten client-owned diabetic dogs on insulin treatment.

Methods: Prospective and observational study. The FGMS was placed on the neck for up to 14 days. During the 1st-2nd, 6-7th, and 13-14th days from application, the IG measurements were compared with the plasma (EDTA) glucose (PG) concentrations analyzed by a reference hexokinase based method.

Results: The application and the use of the FGMS were apparently painless, easy, and well tolerated by all dogs. Mild erythema at the site of the application was found in 5/10 dogs at the end of the wearing period. A good correlation between IG and PG concentrations (rho = 0.94; P < .001) was found. The FGMS was 93, 99, and 99% accurate at low, normal, and high blood glucose concentrations. Mean ± standard deviation difference from the reference method was 2.3 ± 46.8 mg/dL.

Conclusion and clinical importance: The FGMS is easy to use and is accurate for IG glucose measurement in diabetic dogs.

Keywords: Canine; Diabetes mellitus; FreeStyle Libre; Noninvasive glucose measurement.

MeSH terms

  • Animals
  • Blood Glucose / analysis*
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / veterinary*
  • Dog Diseases / blood*
  • Dogs
  • Extracellular Fluid
  • Female
  • Male
  • Monitoring, Physiologic / instrumentation
  • Monitoring, Physiologic / veterinary*

Substances

  • Blood Glucose