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BIODISCOVERY Showcasing the Biosciences...

Welcome to BioDiscovery showcasing the Biological & Biomedical Sciences... topics with videos & activities can be found below which have been created by researchers, lecturers, staff and students at the University of Manchester & Manchester Museum to give you insights into the Biosciences.

Overview of Topics...

  1. Genetic Dreams, Genetic Nightmares - Prof Matthew Cobb
  2. The Vivarium
  3. Invasion of the Biscuit Beetles!
  4. Worms in the Lab
  5. Spider-Man
  6. Stem Cells
  7. The Secret Body - Prof Dan Davis
  8. A Day in the Life of M.Sci. Students
  9. And The Microbes Comics
  10. Our Research with Animals
  11. Revisiting Two Brothers
  12. Making a Covid Vaccine using Plants
  13. The Firs Environmental Research Station
  14. How do Forces affect Cells?
  15. Visualising Nerve Regeneration
  16. Graphic Medicine
  17. Building a Living Biobank for Ovarian Cancer
  18. The Ways We Used to Die - Prof Andrew Doig
  19. Hello Future - Museum Redevelopment

1. GENETIC DREAMS, Genetic nightmares

Professor Matthew Cobb explains the history of genetic engineering and how it has been the focus of dreams and nightmares since the very beginning, from recombinant DNA, through GM crops up to the prospect of genetically engineered humans. Full of interviews with the pioneers and the protestors, this BBC podcast series was broadcast around the globe on the World Service.

Click on the button below to listen...
Professor Matthew Cobb (Faculty of Biology, Medicine and Health) hosts a new series on Radio 4 that looks at fifty years of genetic engineering.

Over the course of three episodes, the series will tell the story of the discovery of genetic engineering in the 1970s, along with the creation of GM crops and in more recent years, the dreams and nightmares around CRISPR genetically engineered humans and gene drives in nature.

The first experiments to combine the DNA of two different organisms began at Stanford University in California in 1971. The revolutionary technique of splicing genes from one lifeform into another promised to be a powerful tool in understanding how our cells worked.

It also offered the prospect of a new cheap means of manufacturing life-saving drugs – for example, by transferring the gene for human insulin into bacteria, growing those genetically engineered microbes in industrial vats and harvesting the hormone. A new industrial revolution based on biology looked possible.

At the same time some scientists and the public were alarmed by disastrous scenarios that genetic engineering might unleash. What if microbes engineered with toxin genes or cancer genes escaped from the labs and spread around the world?

Listen to the podcasts to see what happened next...

2. THE VIVARIUM

The Future of Conservation

Hear from our Vivarium team about the inspiring conservation work that is taking place in the museum and how you can get involved. With the loss of biodiversity due to the impact of the climate crisis, it is more important than ever to conserve our habitats and protect the environment, especially in the global south. As the next generation of herpetologists, it all starts with you!

Sylvia's Tree Frog - a new species:

A new species of frog discovered by Andrew Gray (Curator of Herpetology, Manchester Museum)

Harlequin Frog Conservation:

Critically endangered Harlequin Frog, Atelopus varius, on display at Manchester Museum

Take a look at our Frog Blog:

3. INVASION OF THE BISCUIT BEETLES!

Conservation at the museum...find out more about the (real) infestation!

Pests are a big risk for the museum and we do everything that we can to stop them getting in, but sadly the bugs often outsmart us! When they do get inside and start destroying the collection it can feel like a horror film, but thankfully our curators are trained and know how to protect our collections.

How the Beetles invaded the museum and what happened next!!
4. WORMS IN THE LAB...

How we use worms to investigate transport around the cell...

  • The nematode worm C. elegans can be used as a model organism in biological research because its genes and proteins are similar to humans, it can be easily genetically modified, and it is easy to maintain and handle in the lab environment.
  • In our lab we are interested in the transport of cellular components around the cell by motor proteins – essentially how and why things inside cells get to where they should be.
  • We can use C. elegans to study the transport of such cellular components along neurons by attaching colourful proteins to the components being carried by the motor proteins.
  • In this video we show how we image the transport of the colourful components inside C. elegans neurons using microscopy.

Harvard University teamed up with XVIVO to develop a medical animation that would take cellular biology students on a journey through the microscopic world of a cell...

5. SPIDER-MAN

Manchester Museum’s Spider-Man... Entomology and Taxonomy

Meet Dmitri, Manchester Museum’s Curator of Entomology, and find out more about the collection of arthropods inside the museum’s basement. Come down to the stores to learn about the importance of insects, the work that the museum does, and meet some of Dmitri’s favourite animals- Spiders! If you would like to get involved with our Entomology team, keep an eye on our social media pages for the latest volunteering vacancies.

You can also check out:

6. STEM CELLS

Growing stem cells in the lab:

Have you ever wondered how scientists can grow cells in a lab? Bone cells have a job to make bone, and the job of nerve cells is to pass signals between our brain and our body parts; however, stem cells don’t have a job yet and that is what makes them exciting for the future of healthcare.

We hope that one day stem cells can firstly be told which job to do and secondly they can be implanted to help treat people whose organs and tissues aren’t working properly.

Lynsey, a research student at the University of Manchester, works with stem cells. She will show you what the cells look like under the microscope and will explain some of the basics of cell culture.

How do you think Lynsey knows how many cells she has in the flask? She will show you the method for counting the cells, and we will see if she has enough to begin her next experiment.

How to make your own cell scaffold:

Our bodies are made up of many tiny but soft building blocks, called cells. Have you ever wondered how these cells can hold together? Cells build their own support scaffold, similar to a snail shell, to which they can hold on to.

This scaffold can be soft and flexible, for example in the skin, or very hard, like in the bones. A common part of this scaffold is collagen, which you may have heard from face creams.

Marlene, a research student at the University of Manchester, uses different types of scaffolds to grow cells in the lab. She will show you how you can make your own scaffolds at home using only jelly powder, water, and rice.

How to make your own model hand:

Our hands are incredibly complex, made up of bones, muscles, tendons, and ligaments. These all work together along with signals from your brain which allow your hands to move and pick up things.

Do you want to build a model hand that will aid your visualisation into how this works?

Kathryn, a research student at the University of Manchester will show you how to make a model hand at home from cardboard, paper straws and string.

7. THE SECRET BODY

What Are the New Discoveries in Human Biology? with Professor Daniel Davis and The Royal Institution... watch the talk below:
Back Cover...

We’ll soon know more about our bodies than ever before – but are we ready?

Tests could show the probability of illnesses occurring in five, 10 or 20 years, with huge moral and ethical implications. Photograph: Yuri_Arcurs/Getty Images

Engineered immunity: Redesigning antibodies to better fight disease

Antibodies are a vital weapon in our immune system's arsenal. Now we can redesign them like never before to boost our ability to fight cancer and viruses like HIV

THE wonders of the world tend to be quite conspicuous. You can hardly miss the Grand Canyon, say, or the Great Pyramid of Giza. You could, however, be forgiven for overlooking the great wonders of human biology. It is easy to take the brain or DNA for granted. And yet over the past year or so, living through the coronavirus pandemic, we have all come to better appreciate the marvel that is our immune system, a vast and diverse array of cells and molecules that defend us against viruses and other invaders.

One molecule in particular has taken centre stage: the antibody. These Y-shaped proteins, which we produce in response to infection, are a vital part of our defences. They are also the basis of many of the most important medicines. But we haven’t exhausted their potential yet – far from it.

Typically, we have used antibodies in medicine pretty much as they come in nature, even if we select and mass-produce the versions we need. Now we can do much more. By manipulating genes in the cells that produce antibodies, or splicing together fragments of the proteins themselves, we can re-engineer their structures to create bespoke immune molecules.

In my lab at the University of Manchester, UK, we use super-resolution microscopes to see how the immune system works on a molecular scale. We are just one of thousands of labs doing such work, which is fuelling a new age of antibody engineering. With researchers currently producing all kinds of tailor-made antibodies – from those that lure cancer cells to their doom to those that can actually infiltrate cells …

The Beautiful Cure

The Beautiful Cure: Harnessing your Body's Natural Defences - Times Books of the Year - Royal Society Science Book Prize Shortlist 2018

8. DAY IN THE LIFE OF M.SCI. STUDENTS...

Zebrafish Regeneration

Why can zebrafish regrow fins & heal their heart?

Our aim is to discover the underlying mechanisms to why zebrafish are naturally able to regrow fins and heal their own hearts. This field of research has huge potential in developing future regenerative therapies for humans. We use a variety of types of staining to visualise and study regeneration of the zebrafish heart…

Immunostaining of mutant heart mouse embryos at day E13.5 for the nucleus and cardiomyocytes (cardiac muscle). The blue staining represents DAPI which indicates the nucleus, the green staining represents the myosin heavy chains which will indicate the cardiac muscle or cardiomyocytes and the red staining represents NICD1 which is the intra cellular component of the Notch receptor. We compare wild type mouse embryos with our mutant of interest (Myh10 delta).

Polymerase Chain Reaction

Ever since its invention in 1983, the polymerase chain reaction or PCR, has evolved and become a widely used laboratory technique.
  • PCR is crucial for genetic testing and research, in medical laboratories and for criminal forensics.
  • It can be used on ancient DNA, for day-to-day amplification of DNA or as we have seen during the Covid-19 pandemic, it can identify infection agents such as viruses.
  • The result of the PCR test can be visualised on gels using electrophoresis and the results analysed.
  • During my time in the lab, I have commonly used PCRs to genotype the mice that I work with, and it has been an indispensable technique.
  • Even though simple and basic, when compared to other more intense lab work, PCR is invaluable and has earned its place as an oldie but goldie!

9. AND THE MICROBES COMICS

READ COMIC: LUNA & SIMON - BIZARRE BACTERIA AND PECULIAR PLASMIDS

Join Luna and her sulky brother Simon on a journey into the weird and wonderful world of microbes. Read about the diversity of bacterial life, and the strange ways in which microbes continue to evolve and change our world. Project developed by Professor Michael Brockhurst.

Investigate the amazing science behind Luna and Simon’s adventures! What is a plasmid? How were they discovered? Go behind the scenes with the scientists who investigate these mysteries.

Expand your adventures by downloading our activity packs! Design your own bacterium and colour in scenes from the comic.

Luna & Simon - Short excerpt...
Luna & Simon... read the full comic below...
Downloadable Activities
Funded and Supported by...

10. OUR RESEARCH WITH ANIMALS

The Biological Services Facility is the main location for animal research at the University of Manchester. The facility works with a number of different species across a range of different research disciplines. The work carried out here contributes to breakthroughs in medical science that have wide ranging impact across the globe.

Mice

Our mice are used for a range of experimental work looking at treatments for diseases and conditions such as stroke, mental health problems, heart disease, kidney disease and many others. This research is vital to the worldwide effort in combatting these sometimes devastating diseases. In this video you will be introduced to the area where our mice are kept, and you will see how technicians who care for them work hard to enrich their lives.

Scientists at the University work with some 70,000 mice per year

Sheep

When we are in the countryside, many of us will see flocks of sheep in fields quietly munching away. But amazingly, sheep can also help to provide invaluable insights into the causes and treatments of heart disease and heart failure. This video will show you where the sheep live, how they are used in research and how their lives are enriched by the technicians caring for them.

The university houses between 10-20 sheep in its animal facility

Zebrafish

Despite their small size, the fish can be very useful in researching human disease such as stroke and cancer. They can also give us insight into how the effects of climate change may impact not only human lives but the lives of other fish and aquatic animals. Amazingly, most work with Zebrafish is done before they are 5 days old and less than 1cm in size. This video looks in a little more detail at where Manchester’s Zebrafish live and how they are used in research.

Zebrafish are used in research across the globe in a variety of different areas of science

Have you ever wondered what it’s like inside an animal research unit? Why not pay a visit to our virtual tour, where you can move around in 3D and see mice, rats, fish and sheep. You’ll learn about how our animals are helping scientists find ways to fight disease.

Sometimes we keep goats like this one
Behavioural Study
A paper house provides animals with somewhere to hide, and can act as bedding if chewed up
Xenopus frogs are capable of regrowing toes and even whole limbs!
A zebrafish having heart surgery. Afterwards, this fish will make a full recovery

11. REVISITING THE TWO BROTHERS (PART 2)...

Last year we shared our exciting research into the ‘Two Brothers’, mummies in our collection who were found buried together. If you haven’t seen it, check out Part 1 videos below before watching!

Now we know what the research was and its result, let’s think about the bigger questions that scientists have to consider. Why are we doing this research? Will this cause anyone any harm? Are we doing this for the right reasons?

Part 2:

Take part in our important survey...

Do you think Manchester Museum should have done the DNA test? (click the button below)

Watch Part 1:

Working as ancient biomolecule scientists we analyse DNA, proteins and other biomolecules from really old samples such as mummies and other skeletal remains, animals, plants etc. The DNA from these samples is really old and degraded so we need to wear a forensic suit at all times when we are in the lab, to ensure we don’t contaminate the ancient DNA with our modern DNA...

Ancient DNA Research - who were they?

ONE OF THE ‘TWO BROTHERS’ MUMMIES (KHNUM-NAKHT AND NAKHT-ANKH) 1800BC
It was a long and exhausting journey to the results but we are finally here...
  • Khnum and Nakht have the same mitochondrial DNA and so probably have the same mother but different fathers...
  • A tooth was extracted from each mummy to allow DNA to be extracted.
  • The mitochondrial DNA and Y chromosomes were then compared to see whether the two men shared a mother, father or both.
  • Dr Drosou explains in the video below the analysis that was carried out...

ITV News - How ground-breaking research in Manchester has solved a riddle from ancient Egypt, click on the button below to view:

12. Making a Covid Vaccine using Plants

Expression of SARS-CoV-2 antigens in plants

RNA vaccines against Covid-19 are still a challenge to implement in low- and medium-income countries. This is because RNA vaccines are expensive to produce and need cryogenic storage due to their instability. Using plants to express Covid-19 vaccines is a cost-effective system that can help with this problem. This video describes how lab work with plants is carried out, along with a DNA purification and analysis technique.

13. The Firs Environmental Research Station

Plants from around the world in 3D & Plant Research

This 360° virtual tour lets you travel round the Firs botanical greenhouses and find out about the plants and their adaptations. It can act as a gateway to the site and it would be particularly good for engagement with schools as habitats, photosynthesis, plants and climate change all feature in key stage 1&2 and GCSE curricula.

Learn more about the research at the Firs Research Station

The Firs Experimental Research station is located on the University’s Fallowfield campus, approximately three miles south of the main campus. Historically, the site was part of Sir Joseph Whitworth’s gardens where he carried out tests during the development of his famous Whitworth rifle. The site houses a suite of facilities for environmental research, botanical greenhouses and air pollution monitoring.

A Manchester Air Quality Super Site

The site houses a mobile air quality research laboratory that can gather detailed data on the contents of harmful urban air pollution; working out where the gases and particles that pollute our air are coming from and how they form in the air.

The Firs environmental research station has recently undergone a major £ 2million redevelopment.
  • The 14 state-of-the-art research greenhouses on site can produce a range of different environmental conditions and are used for many areas of research from biofuels to climate change.
  • The botanical greenhouses at the site contains fascinating plants from around the world and represent a number of habitats from deserts, to tropical forests, to Mediterranean climates.
Showy Medinilla (Medinilla magnifica)
Bunny Ears Cactus (Opuntia microdasys)

14. HOW DO FORCES AFFECT CELLS?

How biology, mathematics and frogs can help us understand how cells respond to mechanical forces

Cells in our bodies are constantly experiencing different forces - they’re squashed, stretched and twisted. When this happens the cells don’t just lie down and take it - they take action! Depending on the type of force they are experiencing cells can rearrange, divide or push out neighbouring cells from the tissue.

In early development, embryos go from a simple ball of cells to a complex organism. Different forces are generated throughout early development that helps create the complicated shapes. For example, mechanical force can help align cell divisions in the same direction to specifically elongate a tissue or organ.

In older organisms, cancer changes the mechanics of a tissue making it stiffer than normal. In the Woolner lab, we have shown that cancer cells also stretch the surrounding tissue, causing neighbouring normal cells to divide more, which helps the tumour to grow.

Studying mechanical forces is challenging and requires knowledge from different scientific fields. In this video we introduce you to how we use interdisciplinary research, along with frogs, to study how mechanical forces affect cells in tissues.

Cell division in an epithelial tissue: mitotic spindles can be seen in the central cells – microtubules are stained red, DNA blue and cell membranes green.

Using mathematics to analyse cells in epithelial tissue

Mathematical model applied to epithelial tissue (cell membranes in green, DNA in red). The model can be used to analyse the properties of the cells in the image.

Main Image (left): Using embryos to study early stages of cancer - A common cancer-causing gene (kRasV12, cyan-coloured cells) is expressed in a cluster of epithelial cells (cell membranes in magenta; DNA in yellow) in a Xenopus laevis (African clawed frog) embryo.

15. VISUALISING NERVE REGENERATION

How peripheral nerves regenerate following injury is incompletely understood, but using novel technologies in genetic modification and live cell imaging, we are now able to witness regenerating nerve cells in real-time. Watch the video to find out what this means and how it is achieved.

The ability to visualise in real-time the process of peripheral nerve regeneration has allowed us to observe where and when the cellular skeleton is regenerated following nerve injury. This is achieved through novel genetic manipulation and live imaging techniques of rat peripheral neurons. The question of how this happens is what our research is now focussed on. Answering this ‘how’ question will help us to better understand why patients rarely achieve full recovery following a peripheral nerve injury, why the central nervous system cannot regenerate and crucially, how we might be able to improve nerve regeneration to achieve better patient outcomes.

16. GRAPHIC MEDICINE

Alex is the Curator of Indigenous Perspectives at Manchester Museum, a research illustrator, and a leading expert in graphic medicine! Learn more about how we can communicate health through the medium of comics and the different benefits this can have for different people. Art and science work really well together- and you don’t have to give up your passion for either if you don’t want to!

Continue reading using the link below...
Make your own Comic!
Use these tips to make your very own comic...
Comic template - use this sheet to write your comic

Our pandemic lives are deeply entwined with data visualizations.​ From instructional hand-washing infographics, to calls to ‘flatten the curve,’ data visualisations are telling us how to live, and predicting our possible futures.

As the cascade of open data relating to the COVID-19 virus grows, so too do the charts and graphs claiming to decipher, decode, and translate this data for everyday understanding.

In response to this data visualisation of our everyday lives, designers and data storytellers are working hard to fight graphics that represent ‘fake news’ and educate journalists, analysts and commentators to create better data visualisations.

We created this webcomic to share some of their work and help empower audiences to better understand the COVID-19 data visualisations that now fill our everyday lives.

Why not take a look at:

17. BUILDING A LIVING BIOBANK FOR OVARIAN CANCER

From the patient to the lab...

Data Analysis at the Cancer Research Labs

This virtual lab tour gives you an insight to the working life of a scientist at the Manchester Cancer Research Centre (MCRC)! Our laboratory specialises in cell biology and ovarian cancer, and over the last five years we have created a living biobank containing samples from patients with ovarian cancer.

Thanks to a fantastic collaboration with The Christie Hospital and the MCRC Biobank, we receive samples from patients undergoing treatment at the hospital. Once the sample reaches the lab, we begin separating out the cancer cells from the normal cells so that we can plate them in to flasks and incubate them at 37 degrees, simulating a “human-like” environment.

Once we have successfully established a growing patient culture, we can then investigate how these cancer cells grow and trial current and/or novel chemotherapy drugs to help support the development of new therapies for ovarian cancer.

Using state-of-the-art microscopy, we can screen each patient sample with multiple different drugs and identify how sensitive or resistant they are. This can be compared to other patient samples, or samples from the same patient which we receive over the course of their treatment and see how this sensitivity or resistance changes over time/treatment type.

Performing experiments in the tissue culture hood...
Our team at the Manchester Cancer Research Centre

18. THE WAYS WE USED TO DIE

Causes of death have changed irrevocably across time. In the course of a few centuries we have gone from a world where disease or violence were likely to strike anyone at any age, and where famine could be just one bad harvest away, to one where in many countries excess food is more of a problem than a lack of it.

Why have the reasons we die changed so much? How is it that a century ago people died mainly from infectious disease, while today the leading causes of death in industrialised nations are heart disease and stroke? And what do changing causes of death reveal about how previous generations have lived?

Professor Andrew Doig provides an eye-opening portrait of death throughout history, looking at particular causes - from infectious disease to genetic disease, violence to diet - who they affected, and the people who made it possible to overcome them.

Along the way we hear about the long and torturous story of the discovery of vitamin C and its role in preventing scurvy; the Irish immigrant who opened the first washhouse for the poor of Liverpool, and in so doing educated the public on the importance of cleanliness in combating disease; and the Church of England curate who, finding his new church equipped with a telephone, started the Samaritans to assist those in emotional distress.

This Mortal Coil is a thrilling story of growing medical knowledge and social organisation, of achievement and, looking to the future, of promise.
Professor Andrew Doig, author of This Mortal Coil

19. HELLO FUTURE

What is hello future?

Our Director, Esme Ward, explains what hello future will bring to the people of Manchester and beyond.

We are currently working on a once-in-a-generation transformation called hello future.

Opening February 2023...

Hello future is the £15 million project to transform Manchester Museum. The aim is to build better understanding between cultures and a more sustainable world; and our vision is to become the most inclusive, imaginative, and caring museum you might encounter. We look forward to welcoming visitors from February 2023 with our exciting new galleries and ground-breaking exhibition ‘Golden Mummies of Egypt’. We will see you then!

A brand new two-storey extension has now been built and the stunning South Asia Gallery and Exhibition Hall have been created.

We want to make sure you don't miss out on any of our news about our ground-breaking hello future redevelopment project. We aim to build better understanding between cultures and a more sustainable world. Our vision is to become the most inclusive, imaginative and caring museum you might encounter. This includes the creation of some brand new learning programmes and activities. If you sign up to our E-newsletter you will get a chance to help influence the development of our learning activities...

BIODISCOVERY 2022, UNIVERSITY OF MANCHESTER
These resources were created by all the amazing staff and students at the University of Manchester. We would like to thank all of the following:
  • Professor Mathew Cobb - Genetic Dreams, Genetic Nightmares BBC Radio 4 Podcasts
  • Andrew Gray, Curator of Herpetology at Manchester Museum - The Vivarium
  • Dr Rachel Webster and Abby Stevens - Invasion of the Biscuit Beetles
  • Dr Dmitri Logunov - Spider-Man
  • Astrid Bostrom, Anna Gavrilova and Professor Viki Allan - Worms in the Lab
  • Marlene Polleres, Kathryn Malpas and Lynsey Steel, funded by EPSRC, MRC & Henry Royce Institute (Centre for Doctoral Training Regenerative Medicine) - Stem Cells
  • Professor Daniel Davis - The Secret Body
  • Claudia-Ioana Fifirig and Ewan Egan - Day in the Life of M.Sci. Students
  • Professor Michael Brockhurst, Jamie Hall and Edward Ross - And the Microbes Comics
  • Zachary Bowden, Rachael Bowden, Natasha Allen and Davide Barker - Our Research with Animals
  • Dr Konstantina Drosou, Jack Sharpen and Byron Boggi Ph.D. researcher - KNH Centre for Biomedical Egyptology - Two Brothers
  • Dr Alice Mortimer, Dr Adam J Reid, Dr Raman Das and Medical Research Council - Visualising Nerve Regeneration
  • Team from Firs Environmental Research Station
  • Petr Broz and Dr Anil Day - Making a Covid Vaccine using Plants
  • Emma Johns and Dr Sarah Woolner - How do Forces affect Cells?
  • Dr Alexandra P. Alberda - Graphic Medicine
  • Samantha Littler, Professor Stephen Taylor and Dr Louisa Nelson - Building a Living Biobank for Ovarian Cancer
  • Professor Andrew Doig - The Ways We Used to Die
  • Esme Ward, Manchester Museum Director - Hello Future
  • Manchester Museum Curators and Staff
BioDiscovery Digital - Organisational Team:
  • Dr Shazia Chaudhry (Editor)
  • Dr Lisa Swanton
  • Ellie Chambers (Schools Coordinator, Manchester Museum)
  • Barinur Rashid (Schools Coordinator, Manchester Museum)
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  • Dee-Ann Johnson & Public Engagement Team
  • Michael Addelman & the Media Team
  • Jose Puello & Student Recruitment and Development
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